Comparable outcomes in donation after cardiac death and donation after brainstem death: a matched analysis of renal transplants.

Autor: Pine JK; Department of Transplant Surgery, St James University Hospital, Leeds, West Yorkshire, United Kingdom. james_k_pine@hotmail.com, Goldsmith PJ, Ridgway DM, Cockbain AJ, Farid S, Fraser S, Pollard SG, Attia M, Menon KV, Ahmad N
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2010 Dec; Vol. 42 (10), pp. 3947-8.
DOI: 10.1016/j.transproceed.2010.09.072
Abstrakt: Donation after cardiac death (DCD) donors provide a valuable source of grafts for renal transplantation. They are exposed to an initial warm ischemic insult, which can affect early function. We sought to compare our initial DCD experience in renal transplantation with a case-matched donation after brain death (DBD) cohort from the same period. We included all DCD transplantations in the first 5 years of the program. A control DBD group was matched with a variety of donor and recipient factors. We demonstrated a significantly increased early dysfunction (DGF and primary nonfunction). DCD graft function was poorer than the DBD equivalent at 1- and 3-years. However, medium-term recipient and graft outcomes were comparable. DCD grafts continue to play a vital role in renal transplantation despite evidence of early graft dysfunction.
(Copyright © 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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