| Autor: |
Streffer C, Slanina J, van Beuningen D |
| Jazyk: |
němčina |
| Zdroj: |
Strahlentherapie [Strahlentherapie] 1978 Oct; Vol. 154 (10), pp. 686-91. |
| Abstrakt: |
A correlation between the NAD metabolism and DNA synthesis, that means cell proliferation, was observed in the course of experimental studies using mouse tissues. The present studies revealed a similar correlation also in splenic tissues of patients with Hodgkin's disease. The enzymatic activities of NAD-pyrophosphorylase and NAD-glycohydrolase were measured in detail in isolated cell nuclei. NAD-pyrophosphorylase activity was particularly increased in patients with Hodgkin's disease. A decrease of enzymatic activity was seen following radiation therapy, and especially 24 hours after local irradiation of the spleen with 200 rd(60Co). These studies are in accordance with former results obtained in mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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