| Autor: |
Hsu SD; Department of Anatomy and Cell Biology, University of Cincinnati, Ohio., Jaspers SR, Davis BB, Cardell RR Jr, Miller TB Jr, Drake RL |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of biochemistry and biophysics [Arch Biochem Biophys] 1990 Aug 15; Vol. 281 (1), pp. 152-6. |
| DOI: |
10.1016/0003-9861(90)90425-x |
| Abstrakt: |
Glycogen levels, glycogen synthase activities, and glycogen synthase protein levels were determined in liver tissues obtained from 14- to 19-day-old fetal mice, newborn mice, and adult mice. The results of these experiments demonstrate a significant increase in the quantity of hepatic glycogen synthase beginning at Day 17 of gestation and reaching adult levels at birth. However, during the same time period, there is a dramatic decrease in total glycogen synthase activity suggesting that the accumulating glycogen synthase molecules are unable to transfer UDP-glucose to glycogen. These inversely coordinated changes in the quantity and activity of glycogen synthase are consistent with the suggestion that glycogen synthesis in the near-term fetal mouse is being maintained by preexisting enzyme, while accumulating enzyme molecules may represent a quiescent isozyme. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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