Placental programming of blood pressure in Indian children.

Autor: Winder NR; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, UK. nw@mrc.soton.ac.uk, Krishnaveni GV, Hill JC, Karat CL, Fall CH, Veena SR, Barker DJ
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2011 May; Vol. 100 (5), pp. 653-60. Date of Electronic Publication: 2011 Jan 12.
DOI: 10.1111/j.1651-2227.2010.02102.x
Abstrakt: Aim: To determine whether the size and shape of the placental surface predict blood pressure in childhood.
Methods: We studied blood pressure in 471 nine-year-old Indian children whose placental length, breadth and weight were measured in a prospective birth cohort study.
Results: In the daughters of short mothers (Conclusions: The size and shape of the placental surface predict childhood blood pressure. Blood pressure may be programmed by variation in the normal processes of placentation: these include implantation, expansion of the chorionic surface in mid-gestation and compensatory expansion of the chorionic surface in late gestation.
(© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.)
Databáze: MEDLINE
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