Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder.

Autor: Rodrigues Masruha M; Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil. mmasruha@ig.com.br, Lin J, Arita JH, De Castro Neto EF, Scerni DA, Cavalheiro EA, Mazzacoratti Mda G, Vilanova LC
Jazyk: angličtina
Zdroj: Developmental medicine and child neurology [Dev Med Child Neurol] 2011 Apr; Vol. 53 (4), pp. 378-80. Date of Electronic Publication: 2010 Dec 17.
DOI: 10.1111/j.1469-8749.2010.03854.x
Abstrakt: Spontaneous periodic episodes of hypothermia still defy medical knowledge. In 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebrospinal fluid.
(© The Authors. Journal compilation © Mac Keith Press 2010.)
Databáze: MEDLINE
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