| Autor: |
Gershtein ES; N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. esgershtein@gmail.com, Levkina NV, Digayeva MA, Laktionov KP, Tereshkina IV, Kushlinsky NE |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Oct; Vol. 149 (5), pp. 628-31. |
| DOI: |
10.1007/s10517-010-1010-4 |
| Abstrakt: |
The content of matrix metalloproteinases 7 and 9 was significantly increased, while the content of metalloproteinase 2 was reduced in ovarian cancer tissue compared to benign tumors. In blood serum from patients with ovarian cancer, the concentrations of matrix metalloproteinases 7 and 9 and their type 1 tissue inhibitor were significantly elevated, while the concentration of matrix metalloproteinase 2 was reduced compared to the corresponding parameters in healthy women. After chemotherapy, tissue and serum concentrations of metalloproteinases and their inhibitor in patients practically returned to normal. A significant positive correlation between serum levels of matrix metalloproteinases 7 and 9 and tissue inhibitor of metalloproteinases-1 in patients with ovarian cancer and the size of primary tumor (ultrasound examination) and a positive correlation between these parameters and the concentration of classical ovarian cancer marker CA-125 were demonstrated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink