The Brazilian database on pregnancy in multiple sclerosis.

Autor: Finkelsztejn A; HC de Porto Alegre, Porto Alegre, RS, Brazil., Fragoso YD, Ferreira ML, Lana-Peixoto MA, Alves-Leon SV, Gomes S, Damasceno BP, Mendes MF, Salgado PR, Correa EC, Comini-Frota ER, Diniz DS, Gama PD, Kaimen-Maciel DR, Morales RR, Arruda WO, Grzesiuk AK, Khouri JM, Lopes JS, Rocha CF, Domingues R, Gonçalves MV, Lorenti MA, Parolin MK, Siquineli F, Tosta ED, Brooks JB, Gallina AS, Melges LD, Ruocco HH
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2011 May; Vol. 113 (4), pp. 277-80. Date of Electronic Publication: 2010 Dec 15.
DOI: 10.1016/j.clineuro.2010.11.016
Abstrakt: Objectives: To report the results from the Brazilian database on multiple sclerosis (MS) and pregnancy.
Methods: Retrospective data from MS patients who became pregnant at any time of their disease were sent to a Brazilian database, using a specific file for this purpose.
Results: Data on 128 women (142 pregnancies) from 30 neurologists working in 21 cities in Brazil were collected. Patients' average age at pregnancy was 29.8 years (range 16-42). EDSS at start of pregnancy was 1.5±1.4; and the relapse rate in the year preceding pregnancy was 1.2±1.5. Exposure to medication at any time during pregnancy was high (69.7%): 48.6% to interferon beta; 14.1% to glatiramer acetate; and 7% to other immunomodulatory and immunosuppressive drugs. There was a significant decrease in relapse rate during pregnancy. The prevalence of complications was relatively low, with 4.9% of obstetric and 1.4% neonatal unfavorable outcomes.
Conclusions: Our patients had low degrees of disability, short histories of disease, high drug exposure, and relatively high relapse rate in the year previous to pregnancy. Obstetric and neonatal outcomes were successful in over 90% of our patients.
(Copyright © 2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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