| Autor: |
Cramer JW; Eli Lilly and Co, Lilly Corporate Center, Drop Code 0710, Indianapolis, IN 46285, USA. jcramer@lilly.com, Mattioni BE, Savin KA |
| Jazyk: |
angličtina |
| Zdroj: |
IDrugs : the investigational drugs journal [IDrugs] 2010 Dec; Vol. 13 (12), pp. 857-61. |
| Abstrakt: |
Although the benefit of early ADME screening is widely recognized in the pharmaceutical industry, the implementation of this paradigm is often performed with insufficient resources and poor collaboration between functions. Dedicated and consistent integration efforts of ADME knowledge during the lead generation (LG) phase of drug discovery enables informed resourcing decisions and also increases the quality of initial starting points for discovery projects. To facilitate the efficient and consistent application of ADME resources to early projects at Eli Lilly and Co, a team of scientists was formed to provide dedicated ADME support to the LG phase of the discovery portfolio. This feature review discusses the working construct of the team, the general philosophy that was employed, and the outcomes of this endeavor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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