[Prevalence of HPV 16, 18, 45 and 31 in women with cervical lesions].

Autor:	Pitta DR; Departamento de Tocoginecologia, Centro de Atenção Integral à Saúde, Universidade Estadual de Campinas, SP, Brasil., Campos EA, Sarian LO, Rovella MS, Derchain SF
Jazyk:	portugalština
Zdroj:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2010 Jul; Vol. 32 (7), pp. 315-20.
Abstrakt:	Purpose: To determine the prevalence of HPV 16, 18, 31 and 45 in cervical screening samples of women with cellular changes and/or colposcopy suggestive of persistent high grade or low grade lesion who were submitted to conization. Methods: A total of 120 women were included in the study. Histological analysis of the cervical cones revealed 7 cases of cervicitis, 22 of CIN1, 31 of CIN2, 54 of CIN3, and 6 invasive carcinomas. The cervical screening samples were analyzed before conization for the presence of HPV-DNA by PCR using the consensus primers PGMY09/11. HPV-DNA-positive samples were tested for the presence of HPV16, 18, 31 and 45 using type-specific primers for these HPV. Results: HPV-DNA was detected in 67.5% of the studied women. HPV 16 (40%) was the most prevalent type in most ilesions, followed by HPV 31 (13.3%), 45 (13.3%), and 18 (4.1%). Multiple infections occurred in 15% of the cases and infections with other HPV types were detected in 14% of the sample. Conclusions: HPV 16 and 18 infections do not always occur as a single infection, and may be associated with other HPV types on different occasions.
Databáze:	MEDLINE
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