| Autor: |
Jun D; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic., Musilova L, Pohanka M, Jung YS, Bostik P, Kuca K |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2010 Aug 03; Vol. 11 (8), pp. 2856-63. Date of Electronic Publication: 2010 Aug 03. |
| DOI: |
10.3390/ijms11082856 |
| Abstrakt: |
We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos. Compounds were assayed in concentrations of 10 and 100 μM. In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. The most potent reactivators of inhibited BChE were K033, obidoxime, K117, bis-3-PA, K075, K074 and K127. The reactivation efficacy of tested oximes was lower in case of leptophos-oxon inhibited BChE. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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