Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.

Autor: Lewin G; Laboratoire de Pharmacognosie, (Univ. Paris-Sud 11, BIOCIS, UMR-8076 CNRS), Faculté de Pharmacie, Av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France. guy.lewin@u-psud.fr, Shridhar NB, Aubert G, Thoret S, Dubois J, Cresteil T
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2011 Jan 01; Vol. 19 (1), pp. 186-96. Date of Electronic Publication: 2010 Nov 20.
DOI: 10.1016/j.bmc.2010.11.035
Abstrakt: Eighteen new analogues of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxy-flavone, a potent natural cytotoxic and antimitotic flavone, were synthesized from calycopterin, the major flavonoid of Calycopteris floribunda Lamk., a traditional Asian medicinal plant. One of them, the 3'-amino substituted analogue, displayed almost the same activity as the reference compound. Pharmacomodulation at C-3' on the B-ring, and at C-5,6,7 and 8 on the A-ring allowed to refine structure-activity relationships within the cytotoxic flavones series.
(Copyright © 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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