Asymmetric synthesis of tertiary benzylic alcohols.

Autor: Antczak MI; Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA., Cai F, Ready JM
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2011 Jan 21; Vol. 13 (2), pp. 184-7. Date of Electronic Publication: 2010 Dec 13.
DOI: 10.1021/ol102567h
Abstrakt: Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.
Databáze: MEDLINE