Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.

Autor: Kulkarni NV; Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka, India. vkrevankar@rediffmail.com, Budagumpi S, Kurdekar GS, Revankar VK, Didagi S
Jazyk: angličtina
Zdroj: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2010 Dec; Vol. 58 (12), pp. 1569-75.
DOI: 10.1248/cpb.58.1569
Abstrakt: A novel Cu(II) and Zn(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.
Databáze: MEDLINE