| Autor: |
Wu S; MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China., Xu D, Guo H |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2010 Dec 29; Vol. 132 (51), pp. 17986-8. Date of Electronic Publication: 2010 Dec 07. |
| DOI: |
10.1021/ja104241g |
| Abstrakt: |
QM/MM studies of the hydrolysis of a β-lactam antibiotic molecule (biapenem) catalyzed by a monozinc β-lactamase (CphA) have revealed the complete reaction mechanism and shown that an experimentally determined enzyme-intermediate complex is a stable intermediate or product in a minor pathway. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
