| Autor: |
Fischer G; Centro de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. geferson.fischer@gmail.com, Paulino N, Marcucci MC, Siedler BS, Munhoz LS, Finger PF, Vargas GD, Hübner SO, Vidor T, Roehe PM |
| Jazyk: |
angličtina |
| Zdroj: |
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2010 Nov; Vol. 105 (7), pp. 908-13. |
| DOI: |
10.1590/s0074-02762010000700012 |
| Abstrakt: |
Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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