| Autor: |
Britanova OV; Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Staroverov DB, Chkalina AV, Kotlobay AA, Zvezdova ES, Bochkova AG, Chudakov DM |
| Jazyk: |
angličtina |
| Zdroj: |
Rheumatology international [Rheumatol Int] 2011 Aug; Vol. 31 (8), pp. 1101-3. Date of Electronic Publication: 2010 Nov 30. |
| DOI: |
10.1007/s00296-010-1663-3 |
| Abstrakt: |
Earlier studies have shown that high doses of TNF-alpha increase apoptosis in human autoimmune T-cell clones. Based on these studies, a treatment approach was proposed to reduce or eliminate autoimmune T cells in patients with type 1 diabetes using drugs that temporarily elevate TNF levels. Here, we report the treatment of ankylosing spondylitis patient with a single high oral dose of Likopid (glucosaminyl-muramyl dipeptide), which aimed at increasing the levels of TNF-alpha in order to induce apoptosis of autoreactive T cells. The flow cytometric analysis of blood samples collected before and after treatment demonstrated massive elimination of CD8(+) T cells. However, the treatment did not result in any notable therapeutic effect, and real-time PCR analysis demonstrated that stably expanded T-cell clones that were earlier tracked in this patient were unaffected. This report suggests that the controversial approach to eliminate autoimmune T-cell clones through overstimulation is not effective in treating ankylosing spondylitis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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