| Autor: |
Thibane VS; Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P.O. Box 339, Bloemfontein, 9301, South Africa. ThibaneV@ufs.ac.za, Kock JL, Ells R, van Wyk PW, Pohl CH |
| Jazyk: |
angličtina |
| Zdroj: |
Marine drugs [Mar Drugs] 2010 Oct 08; Vol. 8 (10), pp. 2597-604. Date of Electronic Publication: 2010 Oct 08. |
| DOI: |
10.3390/md8102597 |
| Abstrakt: |
The effect of marine polyunsaturated fatty acids on biofilm formation by the human pathogens Candida albicans and Candida dubliniensis was investigated. It was found that stearidonic acid (18:4 n-3), eicosapentaenoic acid (20:5 n-3), docosapentaenoic acid (22:5 n-3) and docosahexaenoic acid (22:6 n-3) have an inhibitory effect on mitochondrial metabolism of both C. albicans and C. dubliniensis and that the production of biofilm biomass by C. dubliniensis was more susceptible to these fatty acids than C. albicans. Ultrastructural differences, which may be due to increased oxidative stress, were observed between treated and untreated cells of C. albicans and C. dubliniensis with formation of rough cell walls by both species and fibrillar structures in C. dubliniensis. These results indicate that marine polyunsaturated fatty acids may be useful in the treatment and/or prevention of biofilms formed by these pathogenic yeasts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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