HBsAg-negative mono-infection with hepatitis B virus genotype G.
| Autor: | Zaaijer HL; Department of Blood-borne Infections, Sanquin, Plesmanlaan 125, Amsterdam, the Netherlands. h.l.zaaijer@amc.uva.nl, Boot HJ, van Swieten P, Koppelman MH, Cuypers HT |
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| Jazyk: | angličtina |
| Zdroj: | Journal of viral hepatitis [J Viral Hepat] 2011 Nov; Vol. 18 (11), pp. 815-9. Date of Electronic Publication: 2010 Nov 29. |
| DOI: | 10.1111/j.1365-2893.2010.01397.x |
| Abstrakt: | Infection with a genotype G strain of hepatitis B virus (HBV-G) often occurs as a co-infection with HBV genotype A. In mono-infection with HBV-G, the production of hepatitis B surface antigen (HBsAg), HBe antigen and anti-HBe seems diminished, hampering the serological diagnosis of HBV-G mono-infection. To corroborate this notion, we studied in detail a series of samples of a blood donor with transient HBV-G infection. In this donor, during the temporary presence of HBV DNA and the seroconversion to HBcore antibodies (anti-HBc), no HBsAg or hepatitis B e antigen was detected. During follow-up, no anti-HBe appeared. Multiple resistance mutations to lamivudine were present, demonstrating primary infection with a resistant HBV strain. Cloning and sequencing indicated that no other HBV genotype but genotype G was present. Like other HBV-G isolates, the DNA sequence of the HBsAg a-determinant showed no mutations that could explain the failure to detect HBsAg. Our findings demonstrate that HBV genotype G mono-infection occurs and that routine serology is unsuitable for its detection. (© 2010 Blackwell Publishing Ltd.) |
| Databáze: | MEDLINE |
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