Cellular expression of INK4a gene in cells of bladder cancer associated with human papilloma virus-16.

Autor: Volgareva GM; N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. gmvolgareva@front.ru, Zavalishina LE, Golovina DA, Andreeva YY, Ermilova VD, Trofimova OB, Kuevda DA, Shipulina OY, Glazunova VA, Cheng S, Pavlova LS, Cheban NL, Matveev VB, Frank GA
Jazyk: English; Russian
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Aug; Vol. 149 (2), pp. 242-5.
DOI: 10.1007/s10517-010-0917-0
Abstrakt: Hyperexpression of p16(INK4a) protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and p16(INK4a) was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.
Databáze: MEDLINE
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