| Autor: |
Ryazanceva NV; Department for Fundamental Bases of Clinical Medicine, Siberian State Medical University, Russian Ministry of Health Care and Social Development, Tomsk, Russia. rnv@mail.ssmu.ru, Novickiy VV, Zhukova OB, Biktasova AK, Chechina OE, Sazonova EV, Belkina MV, Chasovskih NY, Khaitova ZK |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Aug; Vol. 149 (2), pp. 180-3. |
| DOI: |
10.1007/s10517-010-0902-7 |
| Abstrakt: |
We studied the in vitro apoptosis-inducing effect of recombinant TNF-α (rTNF-α) on blood lymphocytes from healthy donors. rTNF-α-induced apoptosis was accompanied by an increase in the number of cells with low mitochondrial transmembrane potential, increased intracellular content of reactive oxygen species, reduced content of Bcl-2, Bcl-xL, and Bax proteins, and elevated Bad content. The molecular mechanisms of these changes are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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