| Autor: |
Ryazantseva NV; Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia. mv@mail.ssmu.ru, Novitskii VV, Zhukova OB, Biktasova AK, Chechina OE, Sazonova EV, Radzivil TT, Wice AN, Chasovskikh NY |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Jul; Vol. 149 (1), pp. 50-3. |
| DOI: |
10.1007/s10517-010-0873-8 |
| Abstrakt: |
The effect of recombinant TNF-α on programmed death of donor lymphocytes was studied in vitro. The proapoptotic effect of this cytokine is realized through transcription factors and cell cycle inhibitors. Incubation of lymphocytes with recombinant TNF-α revealed increased levels of NF-kB and p21 and reducted content of nonphosphorylated p53. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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