| Autor: |
Lineberry CG; Burroughs Wellcome Co., Research Triangle Park, N.C. 27709., Johnston JA, Raymond RN, Samara B, Feighner JP, Harto NE, Granacher RP Jr, Weisler RH, Carman JS, Boyer WF |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of clinical psychiatry [J Clin Psychiatry] 1990 May; Vol. 51 (5), pp. 194-9. |
| Abstrakt: |
Two hundred twenty-four outpatients with major depression entered a 6-week, five-center, double-blind trial of bupropion 300 mg/day and placebo. A total of 216 patients were included in the efficacy analysis. In the combined center analysis, greater efficacy for bupropion was found on one or more measures (Hamilton Rating Scale for Depression, Montgomery-Asberg Depression Rating Scale, and Clinical Global Impressions) at treatment Days 21, 28, 35, and 42. Bupropion was well tolerated; only four adverse events were reported at least 5% more often in the bupropion group than in the placebo group. Six bupropion patients versus 5 placebo patients discontinued treatment because of adverse events. This study extends earlier findings of efficacy for higher-dose treatment in an inpatient population to lower-dose treatment in an outpatient population. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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