| Autor: |
Alfaresi MS; Department of Pathology and Laboratory Medicine, Zayed Military Hospital, PO BOX 3740, Abu Dhabi, UAE. uaenow@eim.ae |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular biology reports [Mol Biol Rep] 2011 Apr; Vol. 38 (4), pp. 2719-22. Date of Electronic Publication: 2010 Nov 20. |
| DOI: |
10.1007/s11033-010-0415-5 |
| Abstrakt: |
A molecular study was conducted to investigate the prevalence of Hepatitis C virus genotypes in HCV infected population of UAE. 67 HCV seropositive samples were collected from different health care centres. Quantitative analysis of these samples using PCR resulted in 67 positive samples. The PCR positive samples were subjected to genotyping using the method described by Simmonds et al. (J Gen Virol 74: 2391-2399, 1993). HCV genotype 4 was the predominant genotype (46.2%) followed by genotype 3a (23.8%) and 1a (15%). The predominant genotype among the female patients was genotype 4 (65.6%), while genotype 3a was the predominant among the male patients (42.8%). The predominance of HCV genotype 4 in our population confirms the predominance of HCV genotype 4 in UAE and most of the Arab countries in the Middle East. Implications of genotyping for clinical outcome of HCV infection, response to treatment as well as for vaccine development are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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