Influence of AIN-93 diet on mortality and cardiac remodeling after myocardial infarction in rats.

Autor: Ardisson LP; Internal Medicine Department, Botucatu Medical School, UNESP-São Paulo State University, Botucatu, Brazil., Minicucci MF, Azevedo PS, Chiuso-Minicucci F, Matsubara BB, Matsubara LS, Santos PP, Assalin HB, Novo R, Novelli EL, Sant'ana LS, Paiva SA, Zornoff LA
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2012 May 03; Vol. 156 (3), pp. 265-9. Date of Electronic Publication: 2010 Nov 23.
DOI: 10.1016/j.ijcard.2010.10.128
Abstrakt: Background: The AIN-93 diet was proposed by the American Institute of Nutrition with the objective of standardising studies in experimental nutrition. Our objective was to analyze the effects of AIN-93 diet after myocardial infarction in rats.
Methods: Post weaning, the animals were divided into two groups: control (C, n=62), fed the standard diet of our laboratory (Labina); AIN-93 Group (n=70), fed the AIN-93 diet. Achieving 250 g, the animals were subjected to myocardial infarction.
Results: Early mortality was increased in AIN-93 animals, associated with lower serum levels of calcium, magnesium, potassium, sodium, and phosphorus. On the other hand, after 90 days, AIN-93 showed smaller normalized left ventricular dimensions. The caloric and carbohydrate intake was smaller, but the fat intake was higher in AIN-93 rats. AIN-93 group also showed increased levels of β-hydroxyacylcoenzyme A dehydrogenase and citrate synthase. In addition, serum levels of insulin and cardiac levels of malondialdehyde, metalloproteinases-2 and -9, and TNF-α and IFN-γ were decreased in the AIN-93 group.
Conclusion: AIN-93 diet increased early mortality, while attenuated the chronic remodeling process after experimental coronary occlusion. Therefore, this diet has biological effects and should be use with attention in this model.
(Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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