Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.

Autor: Alachkar N; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. nalachk1@jhmi.edu, Ugarte R, Huang E, Womer KL, Montgomery R, Kraus E, Rabb H
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2010 Nov; Vol. 42 (9), pp. 3399-405.
DOI: 10.1016/j.transproceed.2010.06.013
Abstrakt: Introduction: Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.
Methods: We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF.
Results: Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74).
Conclusions: This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
(Copyright © 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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