| Autor: |
Choquette KA; Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA., Sadasivam DV, Flowers RA 2nd |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2010 Dec 15; Vol. 132 (49), pp. 17396-8. Date of Electronic Publication: 2010 Nov 19. |
| DOI: |
10.1021/ja1088925 |
| Abstrakt: |
The presence of HMPA is critical for the selective coupling of alkyl halides and ketones by SmI2. Although previous rate studies have shown that HMPA dramatically accelerates the reduction of alkyl halides over ketones, the basis of this rate acceleration is unknown. In this communication, we report experimental and computational evidence that demonstrate that the selectivity observed in the samarium Barbier reaction is in part a result of activation of the alkyl halide bond by HMPA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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