Alterations in corrected QT interval following liver transplant in patients with end-stage liver disease.
| Autor: | Zurick AO 3rd; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. zuricka@ccf.org, Spier BJ, Teelin TC, Lorenze KR, Alberte C, Zacks S, Lindstrom MJ, Pfau PR, Selzman K |
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| Jazyk: | angličtina |
| Zdroj: | Clinical cardiology [Clin Cardiol] 2010 Nov; Vol. 33 (11), pp. 672-7. |
| DOI: | 10.1002/clc.20801 |
| Abstrakt: | Background: Studies have demonstrated that patients with end-stage liver disease (ESLD) often have a prolonged corrected QT interval (QTc) with variable changes in the QTc post-transplant. We sought to characterize the prevalence and degree of QTc prolongation in ESLD patients, identify risk factors for QTc prolongation, and assess changes in QTc following transplant. Hypothesis: QTc interval is prolonged in ESLD patients pre-transplant due to a variety of risk factors and shortens following liver transplantation. Methods: We conducted a retrospective, multicenter study utilizing 2 large liver-transplant databases. QTc intervals were calculated utilizing Bazett's formula. The cutoff used for prolonged QTc was 440 milliseconds for men and 460 milliseconds for women. Results: There were 269 patients (169 men, 100 women) included in the final analysis. The mean pre-transplant QTc was prolonged (449.0 ms), whereas the mean post-transplant QTc shortened and was within normal limits (416.7 ms) (P < 0.0001). QTc shortened after transplant in 87% of patients. QTc normalized in 70% of patients. Age and Model for End-Stage Liver Disease (MELD) score were not predictive of prolonged QTc at baseline. Conclusions: ESLD patients often have a prolonged QTc, which frequently shortens or normalizes after transplant. Screening for prolonged QTc is warranted if medications known to prolong the QTc interval are used in ESLD patients pre-transplant. MELD score, age, and sex were not predictive of prolonged QTc at baseline. (Copyright © 2010 Wiley Periodicals, Inc.) |
| Databáze: | MEDLINE |
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