| Autor: |
Volgareva GM, Zavalishina LÉ, Trofimova OB, Korolenkova LI, Khachaturian AV, Andreeva IuIu, Ermilova VD, Cheban NL, Kuevda DA, Shipulina OIu, Glazunova VA, Golovina DA, Petrov AN, Matveev VB, Frank GA |
| Jazyk: |
ruština |
| Zdroj: |
Arkhiv patologii [Arkh Patol] 2010 Jul-Aug; Vol. 72 (4), pp. 24-7. |
| Abstrakt: |
A female patient with recurrent bladder cancer underwent complex examination. The primary tumor removed in 2004 showed human papillomavirus (HPV) 16 DNA, mRNA corresponding to HPV16 oncogene E7, as well as HPV16 protein E7. The patient is a smoker who has been working at a chemical factory for over 20 years. During tumor recurrence in 2009, there was no DNA of high-risk HPV types in the cancer cells. HPV16 E7protein and cellular p 16(INK4alpha), an indicator of HPV-induced carcinogenesis, were not found. Colposcopy revealed no precancerous changes in the epithelium of the cervix uteri. The cervical epitheliocytes contained no high-risk HPV DNA, E7 and p16(INK4alpha) proteins. It seems expedient to continue in vitro studies of the possible role of HPV in urothelial carcinogenesis on an experimental model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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