| Autor: |
Cassano WF; Division of Pediatric Hematology-Oncology, University of Florida, Gainesville 32610. |
| Jazyk: |
angličtina |
| Zdroj: |
Blood [Blood] 1990 Apr 01; Vol. 75 (7), pp. 1557-63. |
| Abstrakt: |
We identified a new human, T-lineage restricted glycoprotein of molecular weight 120 Kd that is expressed primarily in mature T-cell malignancies. The antigen, named TCA-1 (T-cell cytoplasmic antigen), is an intracellular glycoprotein found mainly in the Golgi stacks, although a few cell lines also display surface membrane TCA-1. Many but not all T-cell neoplasms express this antigen. The antigen is absent from neoplastic and normal human tissue outside the T-lymphocyte lineage. TCA-1 was identified by murine monoclonal antibodies produced after immunization of mice with T-cell chronic lymphocytic leukemia cells. The glycoprotein is a monomer containing approximately 4% N-linked carbohydrate with terminal D-galactose residues. Partial amino acid sequence analysis of TCA-1 shows homology with an immunoglobulin heavy chain region, which suggests that TCA-1 may belong to the immunoglobulin supergene family of receptor and adhesion molecules. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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