The toxicity of titanium dioxide nanopowder to early life stages of the Japanese medaka (Oryzias latipes).

Autor: Paterson G; Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada. gpaters@uwindsor.ca, Ataria JM, Hoque ME, Burns DC, Metcalfe CD
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2011 Feb; Vol. 82 (7), pp. 1002-9. Date of Electronic Publication: 2010 Nov 11.
DOI: 10.1016/j.chemosphere.2010.10.068
Abstrakt: In this study, fertilized Japanese medaka (Oryzias latipes) embryos were exposed from fertilization to 5 d post-hatch using static non-renewal assays to aqueous suspensions of titanium dioxide nanoparticles (nTiO₂) ranging in nominal concentrations between 0 and 14 μg mL⁻¹. The average size of the nTiO₂ in the stock solution before addition to the test treatments was 87 nm (±14 nm). TiO₂ materials accumulated in a concentration dependent manner on the chorionic filaments of developing medaka embryos with evidence of pericardial edema occurring during embryo development. However, no significant (p > 0.05) increases in mortality relative to control treatments were observed for the nTiO₂ exposed embryos. A concentration dependent increase in cumulative percent hatch was observed at 11 d, indicating that exposure to increasing concentrations of nTiO₂ resulted in the premature hatch of medaka embryos. Post-hatch, a significant proportion of sac fry from the nTiO₂ exposure groups exhibited moribund swimming behavior and these individuals also experienced greater mortality at 15 d post-hatch. Combined, these results demonstrate that exposure to nTiO₂ can impact the development of early life stages of fish.
(Copyright © 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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