Zinc release of Zn₇-metallothionein-3 induces fibrillar type amyloid-β aggregates.

Autor: Durand J; Laboratoire de Chimie de Coordination, Centre National de la Recherche Scientifique, 205 route de Narbonne, 77 Toulouse, France., Meloni G, Talmard C, Vašák M, Faller P
Jazyk: angličtina
Zdroj: Metallomics : integrated biometal science [Metallomics] 2010 Nov; Vol. 2 (11), pp. 741-4. Date of Electronic Publication: 2010 Oct 21.
DOI: 10.1039/c0mt00027b
Abstrakt: The reactive oxygen species H₂O₂ promotes the Zn₇-metallothionein-3 induced Aβ(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn(2+) release, whereas amorphous aggregates are formed by addition of Zn(2+) to Aβ(40).
Databáze: MEDLINE