| Autor: |
Katritzky AR; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu, Abo-Dya NE, Abdelmajeid A, Tala SR, Amine MS, El-Feky SA |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2011 Jan 21; Vol. 9 (2), pp. 596-9. Date of Electronic Publication: 2010 Nov 10. |
| DOI: |
10.1039/c0ob00663g |
| Abstrakt: |
The transprotection of N-Fmoc-cysteine containing di- and tripeptides possessing a free SH group to produce the corresponding S-Fm-cysteine di- and tripeptides bearing a free amino group is accomplished efficiently with DBU in dry THF. The N-Fmoc to S-Fm transformation mechanism is discussed. S-Fm-Cysteine di- and tripeptides readily form amide bonds on coupling with N-(Pg-α-aminoacyl)benzotriazoles and N-(Pg-α-dipeptidoyl)benzotriazoles to give larger peptides. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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