Isolated groin recurrence in vulval squamous cell cancer (VSCC). The importance of node count.

Autor:	Butler JS; Royal Marsden Hospital, Department of Gynaecological Oncology, London, UK. drjohnbutler@gmail.com, Milliken DA, Dina R, Eccles SA, Maghami SG, Jameson C, Mason P, Shepherd JH, Soutter WP, Barton DP
Jazyk:	angličtina
Zdroj:	European journal of gynaecological oncology [Eur J Gynaecol Oncol] 2010; Vol. 31 (5), pp. 510-3.
Abstrakt:	Objective: To determine whether there is a node count which can define an adequate inguinofemoral lymphadenectomy (IFL) in primary VSCC. Methods: A retrospective and prospective review of patients with node negative VSCC who had a full staging IFL. Detection of isolated groin recurrences (IGR) would allow groins with higher risk of groin recurrence to be identified. Results: The median node count of 228 IFLs in 139 patients was eight (0-24). There were six IGR (4.3%). Increased rate of IGR was present in patients with increased age, tumour diameter and depth of invasion, lymphovascular space invasion, unilateral IFL, and moderate/poor tumour grade. In the 138 groins with node counts of eight or greater there were no IGRs compared to six in the patients with either undissected groins or groin node counts less than eight (p = 0.030) Interval to IGR was significantly shorter than other sites of recurrence. Both disease-specific and overall survival were significantly reduced in IGR. Conclusions: An inadequate IFL is a nodal count of less than eight per groin; both these groins and undissected groins are at increased risk of IGR and should have close surveillance.
Databáze:	MEDLINE
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