| Autor: |
Otellin VA, Grigor'ev IP, Zabelinskiĭ SA, Chebotareva MA, Krivchenko AI, Alekseeva OS, Kostkin VB |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 2010 Sep-Oct; Vol. 46 (5), pp. 400-5. |
| Abstrakt: |
Experiments were carried out on the 19-day old rat embryos, the 5- and 45-day old rat pups, and the 1.4-1.5-year old rats. Phospholipids and their fatty acid composition in brain cell nuclei were studied using methods of extraction, two-dimensional thin-layer chromatography, and spectrofluorimetry. In the course of ontogenesis, the percentage of different classes of nuclear phospholipids was changed; at the postembryonic period, the unsaturation index of lipids (phosphatidylcholine and phosphatidylethanolamine) and the content of unsaturated (especially polyenic) fatty acids decreased. Microviscosity of nuclear membranes increased; this changes were also shown earlier in phylogenesis of vertebrates. Thus, the facts revealed in the present work correspond to the recapitulation law. It is suggested that such change of lipid ratio and of composition of their fatty acids as well as of the membrane microviscosity serve for regulation of functions of membrane proteins and have adaptive character. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
