| Autor: |
Kim YJ; Department of Pharmacology, Chung-Ang University, Seoul, South Korea., Jang ER, Lee JC, Seo SJ, Lee MW, Lee CS |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of Chinese medicine [Am J Chin Med] 2010; Vol. 38 (6), pp. 1207-22. |
| DOI: |
10.1142/S0192415X10008573 |
| Abstrakt: |
Microbial products, including lipopolysaccharides, may be involved in the pathogenesis of inflammatory skin diseases. We examined the effect of hirsutenoxime on the Toll-like receptor 4-mediated activation of Akt and nuclear factor (NF)-κB in lipopolysaccharide-stimulated keratinocytes. Hirsutenoxime, a cell signaling Akt inhibitor, and Bay 11-7085, an inhibitor of NF-κB activation, attenuated the lipopolysaccharide-induced expression of Toll-like receptor 4, activation of NF-κB and Akt, and the production of chemokines and reactive oxygen/nitrogen species. Hirsutenoxime may reduce the Toll-like receptor 4 expression-mediated NF-κB activation, which is regulated by the Akt pathway in keratinocytes exposed to lipopolysaccharides. This effect may reduce the skin inflammatory response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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