Antileishmanial sesquiterpenes from the Brazilian red alga Laurencia dendroidea.
| Autor: | da Silva Machado FL; Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Pacienza-Lima W, Rossi-Bergmann B, de Souza Gestinari LM, Fujii MT, Campos de Paula J, Costa SS, Lopes NP, Kaiser CR, Soares AR |
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| Jazyk: | angličtina |
| Zdroj: | Planta medica [Planta Med] 2011 May; Vol. 77 (7), pp. 733-5. Date of Electronic Publication: 2010 Nov 05. |
| DOI: | 10.1055/s-0030-1250526 |
| Abstrakt: | Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: | MEDLINE |
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