Myocardial perfusion imaging using technetium-99m sestamibi in asymptomatic diabetic patients.
| Autor: | Mohagheghie A; Majid Assadi, MDBushehr Research Center for Nuclear Medicine The Persian Gulf Biomedical Sciences Institute, Boostan 19 Alley, Imam Khomeini Street, Bushehr, Iran., Ahmadabadi MN, Hedayat DK, Pourbehi MR, Assadi M |
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| Jazyk: | angličtina |
| Zdroj: | Nuklearmedizin. Nuclear medicine [Nuklearmedizin] 2011; Vol. 50 (1), pp. 3-8. Date of Electronic Publication: 2010 Nov 05. |
| DOI: | 10.3413/nukmed-0318-10-05 |
| Abstrakt: | Unlabelled: Myocardial perfusion single-photon emission computed tomography (SPECT) has been extensively applied in the clinical assessment of patients with diabetes mellitus. The aim of the present study was to evaluate stress technetium-99m sestamibi SPECT MPI perfusion in silent myocardial ischemia and its association with some clinical and laboratory parameters in an asymptomatic diabetic population. Patients, Material, Methods: 83 subjects (age: 57.1±6.9 years) with at least five years history of type 2 diabetes, and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging; angiography was also performed in patients with abnormal MPI. Results: MPI results showed that 58 patients had normal myocardial perfusion, while 25 patients showed perfusion defects (23 reversible and 2 fixed) on MPI. 12 out of the 25 (48%) with abnormal MPI findings represented abnormal angiography. We observed that pretest likelihood of CAD (odds ratio 2.32; 95%-CI: 1.05-5.13; p = 0.038) and higher HbA1c level (odds ratio 1.70; 95%-CI, 1.07-2.71; p = 0.02) were independently associated with abnormal MPI. Conclusion: Occult CAD was present on MPI in 1/3 patients with DM without abnormal electrocardiographic findings or evidence of peripheral arterial disease. |
| Databáze: | MEDLINE |
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