Thalidomide for treatment of refractory epilepsy.

Autor: Palencia G; Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico, Mexico., Martinez-Juarez IE, Calderon A, Artigas C, Sotelo J
Jazyk: angličtina
Zdroj: Epilepsy research [Epilepsy Res] 2010 Dec; Vol. 92 (2-3), pp. 253-7. Date of Electronic Publication: 2010 Oct 28.
DOI: 10.1016/j.eplepsyres.2010.10.003
Abstrakt: We have experimentally shown that thalidomide has strong anticonvulsant properties. In an open label study, eight male patients with refractory epilepsy received thalidomide at daily-doses of 200 mg during 1 year, frequency of seizures before and during treatment were compared. The mean number of seizures before thalidomide administration was 26 ± 4 per month; it decreased to 7 ± 1 along thalidomide therapy. Our results indicate that thalidomide has strong therapeutic effects in refractory epilepsy.
(Copyright © 2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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