Can intraocular lenses deliver antibiotics intracamerally?
| Autor: | Shaw J; Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY 11217, USA., Smith EF, Desai RU, Enriquez B, Schrier A |
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| Jazyk: | angličtina |
| Zdroj: | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2010 Dec; Vol. 26 (6), pp. 587-9. Date of Electronic Publication: 2010 Oct 29. |
| DOI: | 10.1089/jop.2010.0021 |
| Abstrakt: | Purpose: To determine the therapeutic concentrations of moxifloxacin achieved in an artificial anterior chamber by soaking the hydrophobic acrylic AcrySof™ SA60 (Alcon Inc.) intraocular lens (IOL) and the hydrophilic collamer Afinity™ CQ2015 (Staar Inc.) IOL in commercially available moxifloxacin 0.5% (Vigamox™; Alcon Inc.). Methods: Forty IOLs (20 Acrysof SA60 and 20 Afinity CQ2015) were soaked in 1 mL of commercially available moxifloxacin 0.5%: 10 of each IOL for 1 min, and another 10 of each IOL for 10 min. The IOLs were placed on absorbent pads for 10 s on each side to dry excess liquid, and then placed in vials of 10 mL balanced salt solution (BSS™) for 30 min. Five milliliters of the balanced salt solution was removed and analyzed by high-pressure liquid chromatography to determine antibiotic levels. Results: The moxifloxacin levels achieved after soaking the hydrophobic SA60 lens were 0.238 and 0.342 μg/mL for 1 and 10-min soaks, respectively. The moxifloxacin levels achieved after soaking the hydrophilic CQ2015 lens were 0.283 and 0.717 μg/mL for 1 and 10-min soaks, respectively. Conclusions: Both lenses were capable of delivering clinically significant antibiotic levels after a 1-min soak. Moxifloxacin concentrations reached at both 1 and 10-min soak times exceed the MIC(90) of the most common pathogens responsible for postoperative endophthalmitis. The antibiotic-soaked IOL has potential to become a clinically significant technique in the prevention of postoperative endophthalmitis. |
| Databáze: | MEDLINE |
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