A prospective evaluation of cardiac function in patients with chronic myeloid leukaemia treated with imatinib.
| Autor: | Estabragh ZR; Department of Haematology, University of Liverpool, Liverpool, UK., Knight K, Watmough SJ, Lane S, Vinjamuri S, Hart G, Clark RE |
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| Jazyk: | angličtina |
| Zdroj: | Leukemia research [Leuk Res] 2011 Jan; Vol. 35 (1), pp. 49-51. Date of Electronic Publication: 2010 Oct 27. |
| DOI: | 10.1016/j.leukres.2010.08.020 |
| Abstrakt: | In vitro studies have suggested that imatinib may be toxic to cardiac myocytes. Though retrospective studies have not shown clinical heart failure, these did not look for subtle cardiac damage. We have carried out a prospective cardiac assessment in 59 chronic myeloid leukaemia (CML) patients treated with imatinib for a median of 3.4 years, using echocardiography and MUGA scanning, with the latter repeated after a further year. We report no evidence of myocardial deterioration, either at baseline or over 12 months of imatinib treatment. Imatinib cardiotoxicity is not an important clinical consideration for CML patients or their advisors. (Copyright © 2010 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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