Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia.

Autor: ten Berg MJ; Division of Pharmacoepidemiology and Pharmacotherapy, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands., Huisman A, van den Bemt PM, den Breeijen H, Egberts TC, van Solinge WW
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2011 Feb; Vol. 16 (1), pp. 51-7. Date of Electronic Publication: 2010 Oct 27.
DOI: 10.3109/1354750X.2010.526243
Abstrakt: Context: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.
Objective: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.
Materials and Methods: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.
Results and Conclusions: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.
Databáze: MEDLINE
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