| Autor: |
Getoff N; Section of Radiation Biology, Faculty of Life Sciences, University of Vienna, Althanstr.14, UZA IIA-1090 Vienna, Austria. nikola.getoff@univie.ac.at, Danielova I, Hartmann J, Schittl H, Gerschpacher M, Ying S, Quint R, Huber JC |
| Jazyk: |
angličtina |
| Zdroj: |
In vivo (Athens, Greece) [In Vivo] 2010 Sep-Oct; Vol. 24 (5), pp. 727-33. |
| Abstrakt: |
Based on previous investigations on several hormones, 17α-hydroxyprogesterone (17α-HOPRG) was studied in respect to cancer initiation by its metabolites resulting from electron emission. The emission of electrons (e⁻(aq)) from its singlet excited state of 17α-HOPRG and HPLC-analysis of products were studied. Possible carcinogenicity of metabolites originating from 17α-HOPRG and the effect of progesterone (PRG) in this respect were studied in vitro. The results showed that 17α-HOPRG is very sensitive towards oxygen. The highest Q(e⁻(aq)) values were obtained by dissolution and UV-irradiation of substrate in airfree media. 17α-HOPRG metabolites showed a strong anticancer activity, which is, however, lower compared to that of PRG-metabolites. Mixture of both hormones, 17α-HOPRG and PRG, in respect to carcinogenicity showed a synergistic effect of PRG on 17α-HOPRG. Reaction mechanisms are presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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