[Recombinant antibodies for medical protection against bioterrorism agents: the example of anthrax].
| Autor: | Thullier P; Institut de Recherche Biomédicale des Armées, Centre de Recherche du Service de Santé des Armées (CRSSA), 24 avenue des Maquis du Grésivaudan, La Tronche, France. pthullier@yahoo.com, Pelat T, Paucod JC, Vidal D |
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| Jazyk: | francouzština |
| Zdroj: | Biologie aujourd'hui [Biol Aujourdhui] 2010; Vol. 204 (1), pp. 81-6. Date of Electronic Publication: 2010 Apr 08. |
| DOI: | 10.1051/jbio/2009048 |
| Abstrakt: | Recombinant antibodies are a highly successful class of therapeutic molecules, they are well adapted for use against bio-weapons (BW) as they act immediately, are often synergistic with other therapeutic molecules, have a long half-life and are well tolerated. Anthrax is regarded at high risk of being used as BW, and its pathogenic properties depend on toxins, which might be neutralized by antibodies. These toxins are made of three different types of sub-units (PA, LF, EF). Several anti-PA have been developed, including an original approach by our team. We have developed an anti-LF, as recommended by experts. Our anti-PA antibody, and to a lesser extend our anti-LF antibody, will be presented here. (© Société de Biologie, 2010.) |
| Databáze: | MEDLINE |
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