Correlation between pathological distal esophageal acid exposure and ineffective esophageal motility.

Autor:	de Miranda Gomes PR Jr; Department of Surgery, School of Medicine, Federal University of Rio Grande do Sul, Brazil., Pereira da Rosa AR, Sakae T, Simic AP, Ricachenevsky Gurski R
Jazyk:	angličtina
Zdroj:	Acta chirurgica Iugoslavica [Acta Chir Iugosl] 2010; Vol. 57 (2), pp. 37-43.
DOI:	10.2298/aci1002037d
Abstrakt:	Aim: To assess the correlation between esophageal dysmotility, characterized as inefficient esophageal motility (IEM), and the presence of pathological acid reflux due to a structurally defective lower esophageal sphincter (LES), hiatus hernia. (HH), or esophagitis in patients with suspected gastroesophageal reflux disease (GERD). Methods: 311 patients referred for GERD diagnostic procedures in a gastroesopahgeal motility laboratory were included in the study. Patients underwent an interview regarding their clinical symptoms, upper endoscopy (UE), stationary esophageal manometry, and 24-h esophageal pH-metry. The following risk factors of patients in the negative pH-metry group were compared to those in the positive pH-metry group: IEM, defective LES, HH, and esophagitis. The association between IEM and positive pH-metry results was first assessed by means of univariate analysis and later determined with multivariate logistic regression analysis. Results: Out of the total of 311 studied patients, 208 met the inclusion criteria; 88 had normal and 120 had positive pH-metry results. Univariate analysis revealed that the occurrence of IEM, defective LES, and HH was significantly greater in the positive pH-metry group. Following logistic regression analysis, the occurrence of IEM remained significantly greater in the positive pH-metry group. Conclusions: IEM is associated with the presence of abnormal acid reflux, as assessed by 24-h esophageal pH-metry, regardless of the presence of defective LES, HH, or esophagitis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu