Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.

Autor: Silva Fde O; Laboratório de Produtos Naturais do Departamento de Química, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Silva MG, Feng D, de Freitas RM
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2011 Mar; Vol. 82 (2), pp. 255-9. Date of Electronic Publication: 2010 Oct 19.
DOI: 10.1016/j.fitote.2010.10.007
Abstrakt: The depressant and anticonvulsant activities of iso-6-cassine (ISO) from Senna spectabilis (0.5, 1.0 and 1.5mg/kg) injected by oral route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 30 days after the administration and at dose of 1.5mg/kg, it reduced the remaining time of animals on Rota-rod apparatus. Additionally, ISO at doses tested was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole and picrotoxin. These results suggest possible depressant and anticonvulsant activities in mice that need further investigation.
(Copyright © 2010. Published by Elsevier B.V.)
Databáze: MEDLINE
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