Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases.

Autor: Joyner PM; Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019-5251, USA., Cichewicz RH
Jazyk: angličtina
Zdroj: Natural product reports [Nat Prod Rep] 2011 Jan; Vol. 28 (1), pp. 26-47. Date of Electronic Publication: 2010 Oct 07.
DOI: 10.1039/c0np00017e
Abstrakt: A review with 187 references, describing natural products that exhibit bioactive properties relevant to the treatment of protein aggregation-related neurodegenerative diseases (e.g., Huntington's, Parkinson's, and prion diseases) and comparing the chemical properties of these secondary metabolite leads to compounds in clinical use for treating central nervous system conditions.
Databáze: MEDLINE