| Autor: |
Sampah ME; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Ceccato CM, Blankson JN |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2011 Feb; Vol. 27 (2), pp. 183-6. Date of Electronic Publication: 2010 Oct 04. |
| DOI: |
10.1089/aid.2010.0144 |
| Abstrakt: |
Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain viral loads of <50 copies/ml without antiretroviral therapy. While HLA-B*57 and B*5801 alleles are overrepresented in ES, many HLA-B*57/B*5801 patients become chronic progressors (CP). We show here that HIV-1 infection results in similar levels of downregulation of HLA-B*57 and HLA-B*5801 molecules on primary CD4(+) T cells from ES and CP. Thus, differences in HIV-1-mediated downregulation of HLA-B*57/B*5801 molecules do not distinguish ES from CP. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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