| Autor: |
Dimmock JR; College of Pharmacy, University of Saskatchewan, Saskatoon, Canada., Erciyas E, Raghavan SK, Kirkpatrick DL |
| Jazyk: |
angličtina |
| Zdroj: |
Die Pharmazie [Pharmazie] 1990 Oct; Vol. 45 (10), pp. 755-7. |
| Abstrakt: |
1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
