[Tumors of the pineal region: retrospective study of 40 cases].
| Autor: | Ben Ammar CN; Service de Radiothérapie Carcinologique, Institut Salah Azaiz, Tunis., Mnif D, Belghith B, Kochbati L, Frikha H, Gargouri W, Besbes M, Ben Abdallah M, Maalej M |
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| Jazyk: | francouzština |
| Zdroj: | La Tunisie medicale [Tunis Med] 2010 Oct; Vol. 88 (10), pp. 714-20. |
| Abstrakt: | Background: the tumours of the pineal region are rare brain tumours, most common in children and characterized by a large clinical and histologic polymorphism. Aim: to assess the outcome and prognostic factors of 40 patients with primitive pineal region tumours treated at the department of radiotherapy of Salah Azaiz institute. Methods: between January 1977 and December 2000, 40 patients received radiotherapy. There were 22 adults and 18 children (age < 16 years). The mean age was 20.4 years and sex ratio was 2.07. Histologic diagnosis was confirmed in 11 cases; 16 patients had a CT evaluation after 20 Gy radiotherapy and in 13 cases diagnosis was performed with CT aspects ± germinal tumour markers. Target volume varied; 10 had craniospinal irradiation, 16 had local irradiation and 14 had whole brain irradiation with a boost at the tumour bed. Chemotherapy was proposed for metastases and recurrent diseases. Results: survival rates were 87% at 2 years and 74, 5% at 5 years. For children, survival rates were 88% at 2 and 4 years. Eight patients (20%) failed locally and 5 patients (12.5%) had metastasis. Age, performance status and large fields of radiotherapy seem to be associated with prognosis and survival. Conclusion: Pineal tumours and especially germinal tumours are chemosensitive and radiosensitive, care of these tumours is multidisciplinary involving surgery, chemotherapy and radiotherapy. From our study and a review of the literature, we tried to find a therapeutic strategy for tumours of the pineal region. |
| Databáze: | MEDLINE |
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