Evaluation of PvuII and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in post-menopausal women.

Autor: Silva IV; Programa de Pós-Graduação em Biotecnologia/RENORBIO, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil., Rezende LC, Lanes SP, Souza LS, Madeira KP, Cerri MF, Paes MF, Daltoé RD, Chambô-Filho A, Guimarães MC, Graceli JB, Rangel LB
Jazyk: angličtina
Zdroj: Maturitas [Maturitas] 2010 Dec; Vol. 67 (4), pp. 363-7. Date of Electronic Publication: 2010 Sep 29.
DOI: 10.1016/j.maturitas.2010.08.006
Abstrakt: Objective: To evaluate the association of -397T>C and -351A>G single nucleotide polymorphisms (SNPs) - also called PvuII and XbaI, respectively - located on estrogen receptor alpha (ERS1) gene with age at menarche, menopause onset, fertility and miscarriage in a population of post-menopausal women.
Study Design: Cross-sectional study with 273 healthy, high miscegenated, post-menopausal women (mean age of 63.1±9.7 years old). Subjects were genotyped for PvuII and XbaI SNPs by PCR-RFLP and confirmed by automatic sequencing. Reproduction informations (age at menarche, age at menopause, number of pregnancies, fertility rate and miscarriages) were obtained by retrospective study using a questionnaire.
Result(s): Age at menarche, menopause onset, number of pregnancies, total fertility rate, and parity did not seem to be influenced by any of the studied genotypes (chi-square, p>0.05). However, women carrying the xx genotype showed a 44% higher chance of miscarriage, whereas this value did not trespass 16% for any other genotype analyzed. It has been also observed a higher occurrence of miscarriage in association with combined xxpp genotype of ERS1 gene (chi-square, p<0.01).
Conclusion(s): The present data indicate that the studied SNPs on ERS1 gene do not influence the menstrual cycle timing and parity but there is a strong relationship between the xx ERS1 SNP genotype and the incidence of miscarriage in the post-menopausal population analyzed.
(Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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